Journal: Pharmaceutics

Article Title: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia

doi: 10.3390/pharmaceutics14040686

Figure Lengend Snippet: Evaluation of the physical properties of the blended film and Li-HAMNs. ( A ) The photograph of the Li-HAMN patch. Scale bar, 5000 µm. ( B ) SEM images of the Li-HAMN array. Scale bar, 500 µm. ( C ) Confocal micrographs of fluorescent Li-HAMNs. Scale bar, 200 µm. ( D ) FTIR spectrum of CMC-Na, PVA, glycerol, and blended film. ( E ) FTIR spectrum of HA, lidocaine, and Li-HA. ( F ) FTIR spectrum of Li-HA, blended film, and Li-HAMNs.

Article Snippet: PVA (0.4 g), CMC-Na (0.2 g), and glycerin (0.2 g) (Sinopharm Chemical Reagent Co, Ltd., Shanghai, China) were dissolved in distilled water (DW, 10 mL) and stirred at 80 °C for 15 min to obtain a uniform backing layer solution.

Techniques:

Journal: Pharmaceutics

Article Title: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia

doi: 10.3390/pharmaceutics14040686

Figure Lengend Snippet: Evaluation of the physical properties of the PVA/CMC-Na blended film and the force curve of Li-HAMNs. ( A ) Results of the swelling performance of the blended film. ( B ) The static contact angle of the blended film surface. ( C ) The force curve of Li-HAMNs analyzed by the universal testing machine. ( D ) The photo of the flush test of the blended film. ( E ) The tensile stress curve of blend film analyzed by the universal testing machine. ( F ) Shape changes of artificial salivary infiltration of Li-HAMNs.

Article Snippet: PVA (0.4 g), CMC-Na (0.2 g), and glycerin (0.2 g) (Sinopharm Chemical Reagent Co, Ltd., Shanghai, China) were dissolved in distilled water (DW, 10 mL) and stirred at 80 °C for 15 min to obtain a uniform backing layer solution.

Techniques:

Journal: Pharmaceutics

Article Title: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia

doi: 10.3390/pharmaceutics14040686

Figure Lengend Snippet: Cell viability of HOK cells after treatment with the PVA/CMC-Na blended film ( A ), lidocaine powder ( B ), and Li-HAMNs ( C ) (* p < 0.05, ** p < 0.01, *** p < 0.001).

Article Snippet: PVA (0.4 g), CMC-Na (0.2 g), and glycerin (0.2 g) (Sinopharm Chemical Reagent Co, Ltd., Shanghai, China) were dissolved in distilled water (DW, 10 mL) and stirred at 80 °C for 15 min to obtain a uniform backing layer solution.

Techniques: